Surgical pathology criteria– search this site only stanford medical sites ways to give find a person alumni lane library ways to give find a person prostatic adenocarcinoma definition malignant epithelial neoplasm of the prostatic acini and ducts diagnostic criteria presence of any one of the following features, even if only focal, is considered diagnostic of prostatic adenocarcinoma (none are required for diagnosis) circumferential perineural invasion glands adjacent to and indenting nerves is not sufficient as a solitary diagnostic criterion partial surrounding of nerve may be  used as supportive evidence for a diagnosis of carcinoma glomeruloid formations epithelial proliferation projecting into the gland lumen typically a cribriform tuft with a single attachment to the side of the gland resembles a glomerulus in bowman’s space mucinous fibroplasia / collagenous micronodules dense nodules of collagen surrounded and encased  by epithelium frequently entraps epithelial cells frequently appears to represent organized, hyalinized mucin the presence of the following features can also be used to make the diagnosis of carcinoma, but none are specific by themselves and none of them is required generally more than one must be present and the focus must not be explainable as a benign glandular collection nuclear enlargement (moderate) and hyperchromasia large nucleoli nuclei are frequently enlarged, but typically uniform very large or pleomorphic nuclei suggest a non-prostatic primary (or normal seminal vesicle) may be seen in acute inflammation, partial atrophy prominent enlarged nucleoli nucleoli >3 μ are very rare outside of carcinoma enlarged nucleoli but <3 μ, while not diagnostic may still be helpful basal cells have prominent but small nucleoli luminal blue (acidic) mucin or dense pink amorphous secretion may be seen in adenosis and rarely in partial atrophy luminal crystalloids bright red, sharp corners, rectangular may be seen in adenosis do not confuse with fractured corpora amylacea which may have occasional sharp edges sharp luminal border normal glands frequently have an undulating border nuclei consistently lined up basally normal glands usually have nuclei at many levels amphophilic cytoplasm not seen in all carcinomas but helpful when present infiltrative pattern a distinct population of glands surrounding or separating benign glands lack of lobularity crowded, haphazard glands immunohistochemical demonstration of complete absence of basal cells can be confirmatory of a diagnosis of carcinoma but must be interpreted of caution (see supplemental studies) see also: atypical small acinar proliferation (asap) – what to do with a small focus of suspicious glands benign prostate patterns that may simulate carcinoma carcinoma patterns that simulate benign prostate see grading at left for criteria relevant to gleason grading robert v rouse md department of pathology stanford university school of medicine stanford ca. viagra time frame viagra vente libre usa generic viagra online cheap viagra discount viagra generic best price buy viagra malaysia viagra dose for young men discount pharmacy viagra buy cheap viagra Buy generic viagra toronto viagra without a doctor prescription best generic viagra from india Viagra pills how long does it last viagra prescription women cheap viagra buy cheap viagra where can i buy viagra over the counter in the uk viagra vente libre usa cheap viagra online